Uroboros Mkono was a specific manifestation of the virally created Uroboros creature, "birthed" from an anonymous test subject in a TRICELL laboratory. It is possible that Mkono's transformation was triggered by Excella Gionne, who was watching from an enclosed observation deck, so that the creature, created when the Uroboros virus rejected the DNA of its host, would kill BSAA agents Sheva Alomar and Chris Redfield. It was far more dangerous than the Uroboros Test Subject, being much more aggressive and having two cores instead of one. Mkono was defeated through the exploitation of the creature's sensitivity towards extreme heat; the laboratory contained a flamethrower and refueling station originally designed to destroy biohazardous material in case of a leak. Redfield and Alomar used the flamethrower to weaken Mkono and then shot at its exposed vital organs. However it can be brought down by weapons fire. Even on Professional, a well aimed RPG can down it.
|Right arm swing (右腕振りまわし Migiude furimawashi )|
|Huge arm swing (巨大腕振りまわし Kyodai ude furimawashi )|
|Huge arm punch (巨大腕パンチ Kyodai ude panchi )|
|Huge arm grab (巨大腕つかみ Kyodai ude tsukami )|
|Missile arm (腕ミサイル Ude misairu )|
|Tentacle sticking (触手張りつき Shokushu haritsuki )|
Most of its ranged attacks can be dodge by pressing following the necessary button prompts. The best way to fight is to run to a safe distance. There are multiple of gas canister inside the laboratory which can be shoot whenever the creature close to it. By shooting it, it will cause a huge explosion, inflicting damage to the creature. Shoot all the creature clusters that hold its limbs in place to weaken it. With the Uroboros Mkono is in its weakened state, fire an unrelenting barrage of flame using the Flamethrower to reveal the creature's weak spot.
- The word "Mkono" comes from the Swahili word for "arm", which may refer to the grabbing and engulfing nature of the boss.
- Uroboros Mkono is the only Resident Evil 5 creature not to be featured as a figurine, most likely due to its similar appearance to the first Uroboros, other than its larger size within the game.