I have a challenge for all of ya. This happened to me and my freind when we were playin through RE5. We were fighting Uroboros (not Mkono and not Aheri) and we ran out of ammo. So instead, we used our knives to defeat it and we actually did. No joke! Are you guys up to it? Can any of you do that? Report your response. (Note: we got it down to 50% of its health with handguns and when we ran out of ammo, that's when we started slashing at it.)
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