Wesker on Resident Evil 5 has many way to be killed
1:Have Chris grab on to his back and you stab the heck out of him!
2:You grab Wesker and let Sheva do the work.
3:shoot his weak spots.
4 (my FAVORITE):shoot the holy mother of pearl with a unlimited fully maxed out Magnum at him not in weaks spots till hes DEAD!!!
5:Go online and let your partner kill him XD I don't prefer this one XD XD XD!!!pics: