We found out recently that Chris is suffering from a "personal tragedy" in Resident Evil 6. The first thing that jumps into my mind is Claire, or a member of STARS has died. I think that a lot of people are probably jumping to that conclusion. Is it possible that the personal tragedy Chris is suffering from is simply that his team gets killed? We see a number of BSAA agents get exposed to some sort of BOW and get all slimy and explode.