These spiders have kept their abilities to scale walls and ceilings and can often attack from unpredictable angles. They are however easily avoided, taking a moderate amount of damage before dying if fought. If killed, these spiders will disgorge a large number of young spiders which can bite and generally harass the player. This can be avoided by using fire-based weaponry which burns any babies the corpse may have been carrying.
They can also attack at range by spitting at their prey, inflicting Poison status. In the REmake, if confronted with certain weapons (like a shotgun), their abdomen will explode in the direction of their attacker, releasing all of their poison reserves in a big splash, which can be hard to evade if the player is near when that happens.
Due to the Web Spinner's unpredictable nature, the B.O.W. research on it was suspended, and the subjects supposedly destroyed. A Web Spinner had a mutagenic reaction to the attempted killing. It became far more powerful and re-adopted the design of web building. This creature was known as the "Black Tiger".