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Wesker may refer to the following:
- Albert Wesker: One of the Wesker Children, Captain of S.T.A.R.S. and creator of Uroboros virus; First appearing in Resident Evil.
- Alex Wesker: One of the Wesker Children and Spencer's most loyal, Alex was tasked to research an immortality virus for Spencer on Sonido Tortuga Island and ended up being the creator of the T-Phobos Virus.
- Project W: Project W was a eugenics project pioneered by Oswell E. Spencer, which intended to develop an advanced race of human beings.