(Covers information from Anderson's universe)
The White House was once the official residence of the President of the United States, located in Washington, D.C.. Featured at the end of Resident Evil: Retribution, the White House serves as the main base of operations and last stronghold for humanity in the wake of the Global T-Virus pandemic caused by the Umbrella Corporation.
The survivors are presumably taken through an underground path that lead them into the building. Inside, soldiers and other operatives were hard at work mounting and reinforcing the defense against the undead and bio-organic weapons. Janus is given an audience with Wesker inside the Oval Office, and shortly thereafter, Wesker injects her with the T-virus again, restoring her powers. Wesker then reveals to the survivors that they are all that stand against the Red Queen, who intends to destroy humanity with the undead and other mutations created by the T-virus.
All the while, missiles and machine guns are used on airborne enemies as Uber-Lickers trying to get over the wall; flamethrowers and air-crafts fire into the crowds of the undead. Adding to the already terrible state of things, the virus has now created winged abominations, which attack all the air-crafts flying around the White House.
The inside, within the halls at least, is cluttered with supplies, computers and maps for attacks. Some entrances have plastic covering on them, perhaps meaning they only lead to supplies. Wesker takes residence in the Oval Office, which has the windows barricaded and several maps and information screens along the walls.
On the outside, the building has been fortified into a makeshift military base, protected by a large fortified wall surrounding the greater part of its landscape. Missile launchers and spotlights are also mounted on the roof, which machine guns on the balconies in front. The yard is full of tanks and air-crafts, which never cease in use due to attacks by large mutations. On top of the wall, spotlights and searchlights are utilized to keep track of movement and guide everyday movement during the night. Both the wall and the building itself are mounted with .50 caliber machine guns and flame throwers to ward off attacks from the infected and reduce them to ashes. It appears that there was a secondary wall around the current one, given the single operational spotlight and the several broken ones; it was most likely destroyed by the Uber-Lickers and crashing air-crafts.